Acetic Anhydride → 2,6-dimethyl-4H-3,1-benzoxazin-4-one

HRID 1197117Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1197117
[CH3:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([NH2:11])=[CH:4][CH:3]=1.[C:12](OC(=O)C)(=O)[CH3:13]>>[CH3:12][C:13]1[O:8][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]=2[N:11]=1

Komponenten

3

Edukt 2

HCID 7918Acetic AnhydrideHCID 762552-Amino-5-methylbenzoic acid

Produkt 1

HCID 27965282,6-dimethyl-4H-3,1-benzoxazin-4-one

Versuchsvorschrift

45.5 g (0.3 mol) of 5-Methylanthranilic acid are refluxed together with 130 g of acetic anhydride for 3 hours. After the solvent has been evaporated in vacuo, the residue is dissolved in 200 ml of dichloromethane, and the solution is filtered through silica gel. The concentrated filtrate is induced to crystallise with isopropyl ether.

Aufarbeitung

  1. customAfter the solvent has been evaporated in vacuo
  2. dissolutionthe residue is dissolved in 200 ml of dichloromethane
  3. filtrationthe solution is filtered through silica gel
  4. customto crystallise with isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-870075bdc07e436cbec7a3fd48b81d16
Quelldatensatz
uspto-grants-1992_05
Patentnummer
US05116971

Notizen zur Reaktion

Wird geladen…