1,1-Diphenylacetone → N-(2,6-Diisopropyl-phenyl)-3-oxo-4,4-diphenyl-butyramide

HRID 1198032

Reaktionsgleichung

[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([CH3:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:17]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH:26]([CH3:28])[CH3:27])[C:21]=1[N:29]=[C:30]=[O:31])([CH3:19])[CH3:18].C([N-]C(C)C)(C)C.[Li+]>>[CH3:19][CH:17]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH:26]([CH3:27])[CH3:28])[C:21]=1[NH:29][C:30](=[O:31])[CH2:10][C:8](=[O:9])[CH:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[CH3:18]

Komponenten

Edukt 3

HCID 699071,1-Diphenylacetone

HCID 922592,6-Diisopropylphenyl isocyanate

HCID 2724682Lithium diisopropylamide

Produkt 1

HCID 10476844N-(2,6-Diisopropyl-phenyl)-3-oxo-4,4-diphenyl-butyramide

Versuchsvorschrift

The title compound, mp 153°-155° C., was prepared from 1,1-diphenylacetone (5.0 g, 0.023 mol), 2,6-diisopropylphenyl isocyanate (4.6 g, 0.023 mol) and lithium diisopropylamide (0.023 mol) using the procedure described in Example 1.

Quellen und Nachweise

ORD-Eintrag: ord-cb1a8a22de8f436db2be5d5d04df1634
Quelldatensatz: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05278326

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