Water → HCID 178441853, Verbindung

HRID 1198482Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1198482
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10](I)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].[Cu][C:18]#[N:19].O>N1C=CC=CC=1>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:18]#[N:19])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]

Komponenten

5

Edukt 3

HCID 962WaterHCID 178418546HCID 178418546, VerbindungHCID 178441862HCID 178441862, Verbindung

Produkt 1

HCID 178441853HCID 178441853, VerbindungAusbeute 72,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A mixture of 6.4 g of 2-butyl-6-iodo-4(1H)-quinazolinone in 25 ml of pyridine is added 3.6 g of copper(I) cyanide followed by heating at reflux for 16 hours. The reaction mixture is poured into water and stirred at room temperature for 8 hours. The suspension is filtered and the cake washed well with water and air dried. The solid is dissolved in 3:1 chloroform-methanol and dried with MgSO4. The volatiles are evaporated in vacuo to give 3.2 g of the desired product as a solid. m.p. 243°-45° C.

Aufarbeitung

  1. temperatureby heating
  2. temperatureat reflux for 16 hours
  3. filtrationThe suspension is filtered
  4. washthe cake washed well with water and air
  5. customdried
  6. dissolutionThe solid is dissolved in 3:1 chloroform-methanol
  7. dry with materialdried with MgSO4
  8. customThe volatiles are evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-66ca6f44ce0b4c5a8dbd1084a5d79e51
Quelldatensatz
uspto-grants-1994_01
Patentnummer
US05281603

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