Tert-Butylamine → N-tert-butyl-4-propylbenzenesulfonamide

HRID 1198673

Reaktionsgleichung

Reaktionsgleichung von HRID 1198673
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)[CH2:2][CH3:3].[C:14]([NH2:18])([CH3:17])([CH3:16])[CH3:15]>C(Cl)Cl>[C:14]([NH:18][S:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:1][CH2:2][CH3:3])=[CH:5][CH:6]=1)(=[O:12])=[O:11])([CH3:17])([CH3:16])[CH3:15]

Komponenten

4

Edukt 2

HCID 6385Tert-ButylamineHCID 27372224-N-Propylbenzenesulphonyl chloride

Produkt 1

HCID 6470063N-tert-butyl-4-propylbenzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-n-propylbenzenesulfonyl chloride (Lancaster) in anhydrous CH2Cl2 (0.5M solution) cooled to 0° C. under N2 was added t-butylamine (2.2 equiv) slowly through a dropping funnel. After complete addition, the reaction was stirred at room temperature for 12 hours. The CH2Cl2 was removed under reduced pressure, and the residue was extracted into ether and washed with 2N NaOH, H2O and brine. The organic phase was dried over anhydrous MgSO4 and concentrated in vacuo to afford the titled product; Rf =0.46 (3:1 hexane-EtOAc).

Aufarbeitung

  1. additionAfter complete addition
  2. customThe CH2Cl2 was removed under reduced pressure
  3. extractionthe residue was extracted into ether
  4. washwashed with 2N NaOH, H2O and brine
  5. dry with materialThe organic phase was dried over anhydrous MgSO4
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-4baec7ebc0bb47e2930d93cda17f657e
Quelldatensatz
uspto-grants-1994_01
Patentnummer
US05281614

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