Trifluoroacetic acid → HCID 19102810, Verbindung

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Reaktionsgleichung

[CH2:1]([C:5]1[N:6]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[S:37](=[O:44])(=[O:43])[NH:38]C(C)(C)C)=[CH:27][CH:26]=2)[C:7](=[O:23])[N:8]([C:10]2[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:11]=2[C:19]([F:22])([F:21])[F:20])[N:9]=1)[CH2:2][CH2:3][CH3:4].FC(F)(F)C(O)=O.C1(OC)C=CC=CC=1>>[CH2:1]([C:5]1[N:6]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[S:37](=[O:44])(=[O:43])[NH2:38])=[CH:27][CH:26]=2)[C:7](=[O:23])[N:8]([C:10]2[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:11]=2[C:19]([F:20])([F:22])[F:21])[N:9]=1)[CH2:2][CH2:3][CH3:4]

Komponenten

Edukt 3

HCID 6422Trifluoroacetic acid

HCID 7519Anisole

HCID 103942615-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]-2,4-dihydro-2-[5-nitro-2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one

Produkt 1

HCID 19102810HCID 19102810, Verbindung

Versuchsvorschrift

The title compound was prepared from 5-n-butyl-4-[[2'-(N-t-butylsulfamoyl)-biphenyl-4-yl]methyl]-2,4-dihydro-2-[5-nitro-2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (from Step C) by reaction with trifluoroacetic acid in the presence of anisole according to the method of Example 28, Step G. Flash chromatography on silica gel (elution with 0.3% MeOH in CH2Cl2) yielded 60 mg (79%) of the product, homogeneous by TLC in 95:5 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 576 (M+1)+.

Quellen und Nachweise

ORD-Eintrag: ord-7b3f556b9fd844d5a26127c6161ed6e8
Quelldatensatz: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05281614

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