Methane → HCID 19867724, Verbindung
Reaktionsgleichung
[CH3:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:13])[CH:8]=[C:9]([NH2:12])[CH:10]=2)[NH:5][C:4](=[O:14])[CH:3]=1.C>C(O)C>[CH3:1][CH:2]1[C:11]2[C:6](=[C:7]([CH3:13])[CH:8]=[C:9]([NH2:12])[CH:10]=2)[NH:5][C:4](=[O:14])[CH2:3]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A suspension of 4-methyl-6-amino-8-methyl-2-(1H)-quinolone (0.38 g) in absolute ethanol (50 cm3) was hydrogenated at 100° and 2000 p.s.i. (13.7×106Pa) pressure over 10% palladised charcoal (0.05 g) for 72 hours. The cooled solution was then filtered through "Solkafloc" (Trade mark for a cellulose-base filtering aid) and evaporated in vacuo to give a solid which was chromtographed on silica (Merck "MK 60.9385" [Trade Mark]) eluting with methanol:chloroform, 1:50 by volume. Combination and evaporation of appropriate fractions gave a residue which on trituration with ethyl acetate afforded the title compound, m.p. 207°-10°, (0.22 g).