HCID 14989639, Verbindung → 5-amino-2-Pyridinepropanoic acid

HRID 1199684Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1199684
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[N:8][CH:9]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[N:8][CH:9]=1

Komponenten

4

Edukt 1

HCID 14989639HCID 14989639, Verbindung

Produkt 1

HCID 149896425-amino-2-Pyridinepropanoic acidAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 3-(5-nitropyrid-2-yl)propionic acid (4.50 g) in ethanol (140 ml) containing 10% palladium on carbon (0.45 g) was shaken under an atmosphere of hydrogen at 3.4 atmospheres pressure for 1.5 hours. The catalyst was removed by filtration and the filtrate was evaporated to dryness. The residue was recrystallised from acetonitrile to give the title compound (3.43 g) m.p. 118°-120° C.

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated to dryness
  3. customThe residue was recrystallised from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-74ca1669f53f4947a3f1e81b6b1cd7ba
Quelldatensatz
uspto-grants-1990_02
Patentnummer
US04902698

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