Water → HCID 14650455, Verbindung

HRID 1200194Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1200194
Br[C:2]1([C:8]2[O:9][C:10]3[C:18]([CH2:19][C:20]#[N:21])=[CH:17][CH:16]=[CH:15][C:11]=3[C:12](=[O:14])[CH:13]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[OH2:22]>>[C:2]1([C:8]2[O:9][C:10]3[C:18]([CH2:19][C:20]([NH2:21])=[O:22])=[CH:17][CH:16]=[CH:15][C:11]=3[C:12](=[O:14])[CH:13]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 962WaterHCID 146504442-(1-Bromocyclohexyl)-8-cyanomethyl-4-oxo-4H-[1]-benzopyran

Produkt 1

HCID 14650455HCID 14650455, VerbindungAusbeute 57 %

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

2-(1-Bromocyclohexyl)-8-cyanomethyl-4-oxo-4H-[1]-benzopyran (3.0 g) was added to polyphosphoric acid (120 ml) and the mixture was heated on an oil bath at about 120° C. for 2 hours. After standing overnight, water (about 300 ml) was added to decompose polyphosphoric acid. Crystals deposited were filtered off and recrystallized form the mixed solvent of dichloromethane and methanol to obtain the title compound, yield 57%.

Aufarbeitung

  1. filtrationCrystals deposited were filtered off
  2. customrecrystallized form the mixed solvent of dichloromethane and methanol

Quellen und Nachweise

ORD-Eintrag
ord-e6c1a28b1f2b451da736b2207e9f5ead
Quelldatensatz
uspto-grants-1990_02
Patentnummer
US04904690

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