Methanol → Tert-butyl 4-(1-(4-cyano-3-fluorophenyl)-3-(hydroxymethyl)-6-oxo-1,6-dihydropyridazin-4-yloxy)piperidine-1-carboxylate

HRID 1202944

Reaktionsgleichung

Reaktionsgleichung von HRID 1202944
[BH4-:35].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[c:16]([C:31](=[O:32])[O:33][CH3:34])[n:17][n:18](-[c:22]3[cH:23][c:24]([F:30])[c:25]([C:28]#[N:29])[cH:26][cH:27]3)[c:19](=[O:21])[cH:20]2)[CH2:12][CH2:13]1.[CH2:44]1[O:45][CH2:46][CH2:47][CH2:48]1.[CH3:37][CH2:38][O:39][C:40]([CH3:41])=[O:42].[CH3:49][OH:50].[Na+:36].[OH2:43]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[c:16]([CH2:31][OH:32])[n:17][n:18](-[c:22]3[cH:23][c:24]([F:30])[c:25]([C:28]#[N:29])[cH:26][cH:27]3)[c:19](=[O:21])[cH:20]2)[CH2:12][CH2:13]1

Komponenten

8

Edukt 7

HCID 887MethanolHCID 923Sodium ionHCID 962WaterHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 28123BorohydrideHCID 44620996Methyl 4-(1-(tert-butoxycarbonyl)piperidin-4-yloxy)-1-(4-cyano-3-fluorophenyl)-6-oxo-1,6-dihydropyridazine-3-carboxylate

Produkt 1

HCID 44621180Tert-butyl 4-(1-(4-cyano-3-fluorophenyl)-3-(hydroxymethyl)-6-oxo-1,6-dihydropyridazin-4-yloxy)piperidine-1-carboxylate

Quellen und Nachweise

ORD-Eintrag
ord-261b158208084202a5a684ad369b1c12
Quelldatensatz
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

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