Sodium Hydroxide → HCID 178446994, Verbindung

HRID 12066

Reaktionsgleichung

Reaktionsgleichung von HRID 12066
C(N(C(C)C)CC)(C)C.[C:10](Cl)(=[O:15])[CH2:11][CH2:12][CH2:13][CH3:14].Cl.Cl.[N:19]1[C:27]2[CH2:26][CH2:25][NH:24][CH2:23][C:22]=2[S:21][C:20]=1[NH:28][C:29]([NH2:31])=[NH:30].[OH-].[Na+]>CN(C)C=O.C(OCC)(=O)C>[C:10]([CH:23]1[C:22]2[S:21][C:20]([NH:28][C:29]([NH2:31])=[NH:30])=[N:19][C:27]=2[CH2:26][CH2:25][NH:24]1)(=[O:15])[CH2:11][CH2:12][CH2:13][CH3:14]

Komponenten

7

Edukt 4

HCID 14798Sodium HydroxideHCID 61186Valeryl chlorideHCID 81531DiisopropylethylamineHCID 178478794HCID 178478794, Verbindung

Produkt 1

HCID 178446994HCID 178446994, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Diisopropylethylamine (0.22 mmol) and then pentanoyl chloride (0.11 mmol) are added to a stirred suspension of N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine-dihydrochloride (0.1 mmol) in dimethylformamide (0.7 ml) and the reaction mixture is stirred for another 16 hours at room temperature. After the addition of 2M caustic soda solution (1 ml) extraction is carried out with ethyl acetate. The combined organic phases produce the pure title compound after drying over sodium sulphate and concentrating to dryness.

Quellen und Nachweise

ORD-Eintrag
ord-98496fd20a5141068171bd4a1a3cc0ec
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727979B2

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