Sodium Hydroxide → HCID 178454398, Verbindung

HRID 12067

Reaktionsgleichung

Reaktionsgleichung von HRID 12067
C(N(C(C)C)CC)(C)C.[CH:10]([CH2:12][C:13]([OH:15])=O)=[CH2:11].N1C2C=CC=C(O[P+](N(C)C)(N(C)C)N(C)C)C=2N=N1.F[P-](F)(F)(F)(F)F.Cl.Cl.[N:45]1[C:53]2[CH2:52][CH2:51][NH:50][CH2:49][C:48]=2[S:47][C:46]=1[NH:54][C:55]([NH2:57])=[NH:56].[OH-].[Na+]>CN(C)C=O>[C:13]([N:50]1[CH2:51][CH2:52][C:53]2[N:45]=[C:46]([NH:54][C:55]([NH2:57])=[NH:56])[S:47][C:48]=2[CH2:49]1)(=[O:15])[CH2:12][CH:10]=[CH2:11]

Komponenten

7

Edukt 5

HCID 14798Sodium HydroxideHCID 327433-Butenoic acidHCID 81531DiisopropylethylamineHCID 178478794HCID 178478794, VerbindungHCID 178486078HCID 178486078, Verbindung

Produkt 1

HCID 178454398HCID 178454398, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Diisopropylethylamine (0.22 mmol), vinyl acetic acid (0.11 mmol) and benzotriazolyloxy-tris-(dimethylamino)phosphonium-hexafluorophosphate (0.11 mmol) are added successively to a stirred suspension of N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine-dihydrochloride (0.1 mmol) in dimethylformamide (0.7 mL), and the reaction mixture is stirred for 16 hours at room temperature. After the addition of 2M caustic soda solution (1 ml) there is extraction with ethyl acetate. The combined organic phases produce the pure title compound after drying over sodium sulphate and concentrating to dryness.

Aufarbeitung

  1. extractionextraction with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-fecbe090558448a4a06f30a565bfc4fc
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727979B2

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