Citraconic Anhydrides → N-(5-bromopyridin-2-yl)-methylmaleimide
Reaktionsgleichung
[C:1]1(=[O:8])O[C:5](=[O:6])[CH:4]=[C:2]1[CH3:3].[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][N:11]=1>C1(C)C=CC=CC=1>[Br:16][C:13]1[CH:14]=[CH:15][C:10]([N:9]2[C:5](=[O:6])[CH:4]=[C:2]([CH3:3])[C:1]2=[O:8])=[N:11][CH:12]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of citraconic anhydride (1.00 mL, 11.1 mmol) and 2-amino-5-bromopyridine (1.93 g, 11.2 mmol) in toluene (60 mL) was heated to reflux overnight. The solution was cooled down, filtered. The filtrate was concentrated in vacuo to give a solid (2.10 g, yield: 71%). MS 267 and 269 (M+H).
Aufarbeitung
- temperaturewas heated
- temperatureto reflux overnight
- temperatureThe solution was cooled down
- filtrationfiltered
- concentrationThe filtrate was concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-e3397632786e4f3d840b2b82c219eed2
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07727981B2
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