O-Methyltyramine → 8-Indan-5-yl-2-(2-(4-methoxy-phenyl)-ethylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

HRID 12347

Reaktionsgleichung

Reaktionsgleichung von HRID 12347
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH2:11])=[CH:5][CH:4]=1.[CH2:12]([O:14][C:15]([C:17]1[C:18](=[O:40])[C:19]2[CH:24]=[N:23][C:22](S(C)(=O)=O)=[N:21][C:20]=2[N:29]([C:31]2[CH:32]=[C:33]3[C:37](=[CH:38][CH:39]=2)[CH2:36][CH2:35][CH2:34]3)[CH:30]=1)=[O:16])[CH3:13]>>[CH2:12]([O:14][C:15]([C:17]1[C:18](=[O:40])[C:19]2[CH:24]=[N:23][C:22]([NH:11][CH2:10][CH2:9][C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)=[N:21][C:20]=2[N:29]([C:31]2[CH:32]=[C:33]3[C:37](=[CH:38][CH:39]=2)[CH2:36][CH2:35][CH2:34]3)[CH:30]=1)=[O:16])[CH3:13]

Komponenten

3

Edukt 2

HCID 4657O-MethyltyramineHCID 252229828-Indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Produkt 1

HCID 685833418-Indan-5-yl-2-(2-(4-methoxy-phenyl)-ethylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

Versuchsvorschrift

Using the procedure outlined in Example 1 Step F, the title compound was prepared from 2-(4-methoxy-phenyl)-ethylamine and 8-indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (Example 1 Step E, 20 mg, 0.040 mmol). 16 mg of 8-Indan-5-yl-2-(2-(4-methoxy-phenyl)-ethylamino)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid.

Quellen und Nachweise

ORD-Eintrag
ord-919543a4f7864fcdaad14c824ac2a07e
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728003B2

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