Cyclohexylamine → Ethyl 3-(cyclohexylamino)propanoate

HRID 12348

Reaktionsgleichung

Reaktionsgleichung von HRID 12348
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:8]([O:10][C:11](=[O:15])[CH2:12][CH2:13]Cl)[CH3:9].C([O-])([O-])=O.[K+].[K+]>[I-].C([N+](CCCC)(CCCC)CCCC)CCC>[CH2:8]([O:10][C:11](=[O:15])[CH2:12][CH2:13][NH:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[CH3:9]

Komponenten

5

Edukt 3

HCID 7965CyclohexylamineHCID 11430Potassium CarbonateHCID 69341Ethyl 3-chloropropionate

Produkt 1

HCID 243063Ethyl 3-(cyclohexylamino)propanoateAusbeute 72,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 67553Tetrabutylammonium IodideKatalysator

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Cyclohexylamine (0.86 g, 8.7 mmol) and 3-chloro-propionic acid ethyl ester (1.18 g, 8.67 mmol) were combined neat and K2CO3 (1.2 g, 8.7 mmol) and a catalytic amount of tetrabutylammonium iodide (ca. 5 mg) was added. The mixture was heated at 80° C. overnight. The resulting mixture was then partitioned between water and dichloromethane. The organic layer was dried (MgSO4) and concentrated to afford 1.25 g (72%) of the title compound.

Aufarbeitung

  1. customThe resulting mixture was then partitioned between water and dichloromethane
  2. dry with materialThe organic layer was dried (MgSO4)
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-66ca2717a0e24c2293f8cef297ade30e
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728003B2

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