Acetic Anhydride → N-(4-Chloro-3-nitrophenyl)acetamide

HRID 1242044

Reaktionsgleichung

Reaktionsgleichung von HRID 1242044
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(Cl)Cl>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:12](=[O:14])[CH3:13])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 124774-Chloro-3-nitroaniline

Produkt 1

HCID 79672N-(4-Chloro-3-nitrophenyl)acetamideAusbeute 101,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirred solution of 4-chloro-3-nitroaniline (51.8 g, 0.36 mol) in anhydrous DCM (300 mL) was added dropwise acetic anhydride (45 mL, 0.48 mol) at room temperature, and the resulting solution was stirred at room temperature for 3 h. The solvent was removed in vacuo, and Et2O was added to the residue. The precipitates were collected by filtration, washed thoroughly with Et2O, and dried under high vacuum to give 4′-chloro-3′-nitroacetanilide (78.7 g, 100%).

Aufarbeitung

  1. customThe solvent was removed in vacuo, and Et2O
  2. additionwas added to the residue
  3. filtrationThe precipitates were collected by filtration
  4. washwashed thoroughly with Et2O
  5. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-74bef879f0de46b89e8eae68ef284cc5
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07115640B2

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