Hydrochloric Acid → HCID 21936741, Verbindung

HRID 1242072Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1242072
C(OC([N:8]1[CH2:17][CH2:16][C:11]2([O:15][CH2:14][CH2:13][O:12]2)[CH2:10][CH:9]1[CH2:18][N:19]1[C:27](=[O:28])[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:20]1=[O:29])=O)(C)(C)C.[ClH:30]>ClCCl.C(OCC)C>[ClH:30].[O:12]1[C:11]2([CH2:16][CH2:17][NH:8][CH:9]([CH2:18][N:19]3[C:20](=[O:29])[C:21]4[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:27]3=[O:28])[CH2:10]2)[O:15][CH2:14][CH2:13]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 69585793HCID 69585793, Verbindung

Produkt 1

HCID 21936741HCID 21936741, VerbindungAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To the above 7-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-1,4-dioxa-8-aza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester (1.1 g, 2.7 mmol) dissolved in dichloromethane (6 ml) was added 1.0 N hydrogen chloride in diethyl ether (50 ml) and the solution kept at ambient temperature for 62 h. The precipitate was filtered off and washed with diethyl ether and dried with nitrogen which afforded 0.83 g (90%) of 2-(1,4-dioxa-8-aza-spiro[4.5]dec-7-ylmethyl)-isoindole-1,3-dione hydrochloride as a solid.

Aufarbeitung

  1. filtrationThe precipitate was filtered off
  2. washwashed with diethyl ether
  3. customdried with nitrogen which

Quellen und Nachweise

ORD-Eintrag
ord-cfc5034c04284363a8300efda199ffa4
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07115624B1

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