Di-tert-butyl dicarbonate → 2-Methyl-2-(3-methylaminomethyl-phenoxy)-propionic acid ethyl ester

HRID 1242376Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1242376
[CH2:1]([O:3][C:4](=[O:17])[C:5]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH2:16])[CH:10]=1)([CH3:7])[CH3:6])[CH3:2].[C:18](OC(OC(C)(C)C)=O)(OC(C)(C)C)=O.C(=O)([O-])O.[Na+]>O1CCOCC1.O>[CH2:1]([O:3][C:4](=[O:17])[C:5]([CH3:7])([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][NH:16][CH3:18])[CH:10]=1)[CH3:6])[CH3:2]

Komponenten

5

Edukt 3

HCID 90495Di-tert-butyl dicarbonateHCID 516892Sodium BicarbonateHCID 580095732-(3-Aminomethyl-phenoxy)-2-methyl-propionic acid ethyl ester

Produkt 1

HCID 670722732-Methyl-2-(3-methylaminomethyl-phenoxy)-propionic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 218864351,4-Dioxane--water (1/1)Lösungsmittel

Versuchsvorschrift

In analogy to the procedures described in example 5D], 5E] and 5F], 2-(3-aminomethyl-phenoxy)-2-methyl-propionic acid ethyl ester was converted into the corresponding tert-butoxycarbonylamino derivative by treatment with di-tert-butyl dicarbonate and sodium hydrogen carbonate in dioxane/water at r.t., methylated at N and deprotected again to yield the title compound as a yellow oil.

Quellen und Nachweise

ORD-Eintrag
ord-ff82aaedb2a14172b8c9c777fda98549
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07115611B2

Notizen zur Reaktion

Wird geladen…