Lithium Hydroxide → HCID 21935777, Verbindung

Reaktionsgleichung

C([O:3][C:4](=[O:39])[C:5]([CH3:38])([O:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:17]=[N:18][C:19]([C:26]3[CH:31]=[CH:30][C:29]([O:32][C:33]([F:36])([F:35])[F:34])=[CH:28][CH:27]=3)=[CH:20][C:21]=2[C:22]([F:25])([F:24])[F:23])=[CH:10][C:9]=1[CH3:37])[CH3:6])C.[Li+].[OH-]>>[CH3:38][C:5]([O:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[CH:17]=[N:18][C:19]([C:26]3[CH:27]=[CH:28][C:29]([O:32][C:33]([F:35])([F:36])[F:34])=[CH:30][CH:31]=3)=[CH:20][C:21]=2[C:22]([F:23])([F:24])[F:25])=[CH:10][C:9]=1[CH3:37])([CH3:6])[C:4]([OH:39])=[O:3]

Komponenten

Edukt 2

HCID 3939Lithium Hydroxide

HCID 86597822HCID 86597822, Verbindung

Produkt 1

HCID 21935777HCID 21935777, Verbindung

Versuchsvorschrift

In analogy to the procedure described in example 26C], 2-methyl-2-{2-methyl-4-[6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-pyridin-3-ylmethoxy]-phenoxy}-propionic acid ethyl ester was treated with 1 N aqueous LiOH solution to give the title compound as yellow crystals.

Quellen und Nachweise

ORD-Eintrag: ord-c50dec506b5e463fab54fccefc396a2a
Quelldatensatz: uspto-grants-2006_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07115611B2

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