1-Bromooctane → 1-Bromo-4-(4-octoxyphenyl)benzene

HRID 1243250

Reaktionsgleichung

Reaktionsgleichung von HRID 1243250
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Br[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 81401-BromooctaneHCID 11430Potassium CarbonateHCID 950934-Bromo-4'-hydroxybiphenyl

Produkt 1

HCID 28017871-Bromo-4-(4-octoxyphenyl)benzeneAusbeute 66 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6569Methyl Ethyl KetoneLösungsmittel

Versuchsvorschrift

A mixture of 4-bromo-4′-hydroxybiphenyl (50.00 g, 0.2008 mol), 1-bromooctane (50.38 g, 0.2610 mol), potassium carbonate (47.11 g, 0.3414 mol) and butanone (500 cm3) was heated under reflux overnight. The cooled mixture was filtered and the solvent removed on a rotary evaporator. The crude solid was recrystallised from ethanol to yield a white crystalline solid (47.30 g, 66%, m.pt. 120° C.).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux overnight
  3. filtrationThe cooled mixture was filtered
  4. customthe solvent removed on a rotary evaporator
  5. customThe crude solid was recrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-25cd1da99c1943748b340fcf01f82f0e
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07118787B2

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