2-Bromopyridine → 1-(PYRIDIN-2-YL)-1,4-DIAZEPANE

HRID 1243328Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1243328
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1>O>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[N:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

Komponenten

4

Edukt 2

HCID 79732-BromopyridineHCID 68163Hexahydro-1,4-diazepine

Produkt 1

HCID 27724021-(PYRIDIN-2-YL)-1,4-DIAZEPANE

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 2-bromopyridine and 12 g of homopiperazine is heated at 100° C. for 6 hours. 50 ml of water are added to the reaction mixture and the resulting mixture is extracted with EtOAc, the organic phase is washed with saturated NaCl solution and dried over Na2SO4, and the solvent is evaporated off under vacuum. 1.28 g of the expected product are obtained.

Aufarbeitung

  1. extractionthe resulting mixture is extracted with EtOAc
  2. washthe organic phase is washed with saturated NaCl solution
  3. dry with materialdried over Na2SO4
  4. customthe solvent is evaporated off under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-6e8e0d76255349c9aaacd4e64da19443
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07119086B2

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