4-Bromopyridine → 1-pyridin-4-yl-1,4-diazepane

HRID 1243329Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1243329
Br[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[NH:8]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[OH-].[Na+]>O>[N:5]1[CH:6]=[CH:7][C:2]([N:8]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:3][CH:4]=1

Komponenten

5

Edukt 3

HCID 142684-BromopyridineHCID 14798Sodium HydroxideHCID 68163Hexahydro-1,4-diazepine

Produkt 1

HCID 27605081-pyridin-4-yl-1,4-diazepaneAusbeute 40,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 2 g of 4-bromopyridine and 10 g of homopiperazine is heated at 100° C. for 4 hours. 100 ml of water are added to the reaction mixture and the resulting mixture is basified to pH 10 by addition of 10% NaOH solution and extracted three times with 100 ml of chloroform, the organic phase is dried over Na2SO4 and the solvent is evaporated off under vacuum. 0.9 g of the expected product is obtained.

Aufarbeitung

  1. extractionextracted three times with 100 ml of chloroform
  2. dry with materialthe organic phase is dried over Na2SO4
  3. customthe solvent is evaporated off under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-e45bd25b6bab40cb95ed25343601ba20
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07119086B2

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