Erythrose, 4-phosphate → D-erythritol 4-phosphate

HRID 1244185

Reaktionsgleichung

Reaktionsgleichung von HRID 1244185
[Na].[P:2]([O:6][CH2:7][C@@H:8]([OH:13])[C@@H:9]([OH:12])[CH:10]=[O:11])([OH:5])([OH:4])=[O:3].[BH4-].[Na+]>CO>[P:2]([O:6][CH2:7][C@@H:8]([OH:13])[C@@H:9]([OH:12])[CH2:10][OH:11])([OH:4])([OH:5])=[O:3]

Komponenten

5

Edukt 3

HCID 122357Erythrose, 4-phosphateHCID 4311764Sodium borohydrideHCID 5360545Sodium

Produkt 1

HCID 192838D-erythritol 4-phosphate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The sodium salt of D-erythrose 4-phosphate (14.6 mg, 65.7 μmol) is dissolved in methanol (600 μl, 40% (v/v)). Sodium borohydride is added. The reaction is monitored by detection of the aldehyde according to the method of Stahl (Bollinger, H. R., Brenner, M., Gänshirt, H., Mangold, H. K., Seiler, H., Stahl, E. ad Waldi, D. (1964) IN: Dünnschicht-Chromatographie; Ein Laboratoriumshandbuch (ed. Stahl, E.) Springer Verlag, Berlin, Göttingen; Heidelberg). After consumption of the aidehyde the pH of the solution is adjusted with acetic acid to 4–5. The reaction mixture is lyophillized yielding D-erythritol 4-phosphate as a dry compound.

Aufarbeitung

  1. customAfter consumption of the aidehyde the pH of the solution

Quellen und Nachweise

ORD-Eintrag
ord-fa0f741e1a644be59ee09747885d4a0b
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07122331B1

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