Ribose 5-phosphate → D-Ribitol 5-phosphate

HRID 1244186

Reaktionsgleichung

Reaktionsgleichung von HRID 1244186
[Na].[P:2]([O:6][CH2:7][C@@H:8]([OH:15])[C@@H:9]([OH:14])[C@@H:10]([OH:13])[CH:11]=[O:12])([OH:5])([OH:4])=[O:3].[BH4-].[Na+]>CO>[P:2]([O:6][CH2:7][C@@H:8]([OH:15])[C@@H:9]([OH:14])[C@@H:10]([OH:13])[CH2:11][OH:12])([OH:4])([OH:5])=[O:3]

Komponenten

5

Edukt 3

HCID 77982Ribose 5-phosphateHCID 4311764Sodium borohydrideHCID 5360545Sodium

Produkt 1

HCID 151104D-Ribitol 5-phosphate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The sodium salt of D-ribose 5-phosphate (18.5 mg, 67.5 μmol) is dissolved in methanol (600 μl, 40% (v/v)). Sodium borohydride is added. The reaction is monitored by detection of the aldehyde according to the method of Stahl (Bollinger, H. R., Brenner, M., Gänshirt, H., Mangold, H. K., Seiler, H., Stahl, E. ad Waldi, D. (1964) IN: Dünnschicht-Chromatographie; Ein Laboratoriumshandbuch (ed. Stahl, E.) Springer Verlag, Berlin, Göttingen; Heidelberg). After consumption of the aldehyde the pH of the solution is adjusted with acetic acid to 4–5. The reaction mixture is lyophillized yielding D-ribitol 5-phosphate as a dry compound.

Aufarbeitung

  1. customAfter consumption of the aldehyde the pH of the solution

Quellen und Nachweise

ORD-Eintrag
ord-c0e5ce2d08bf4f2b9bc3ca9883ddf172
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07122331B1

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