HCID 10336428, Verbindung → Methyl 1-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylate

HRID 1244549Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1244549
[CH3:1][O:2][C:3]([CH:5]1[CH2:9][C:8](=[O:10])[N:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17]CC3C=CC=CC=3)=[CH:13][CH:12]=2)[CH2:6]1)=[O:4]>O1CCCC1.[Pd]>[CH3:1][O:2][C:3]([CH:5]1[CH2:9][C:8](=[O:10])[N:7]([C:11]2[CH:12]=[CH:13][C:14]([OH:17])=[CH:15][CH:16]=2)[CH2:6]1)=[O:4]

Komponenten

4

Edukt 1

HCID 10336428HCID 10336428, Verbindung

Produkt 1

HCID 2883518Methyl 1-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylateAusbeute 115,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

7.26 g (22.3 mmol) (RS)-1-(4-benzyloxy-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester is dissolved in 200 ml tetrahydrofuran. After addition of 726 mg palladium 10% on charcoal hydrogenation is performed at RT and normal pressure. After 3 hours, the catalyst is filtered off and the solvent evaporated to yield 6.04 g of crude product (used in the next step without further purification).

Aufarbeitung

  1. customis performed at RT
  2. filtrationthe catalyst is filtered off
  3. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-e976cf8821904377825ce9521d6860eb
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07122562B2

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