Itaconic acid → (RS)-1-[2,5-difluoro-4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid
Reaktionsgleichung
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=2)[C:5]([F:17])=[CH:4][C:3]=1[NH2:18].[C:19]([OH:27])(=[O:26])[C:20]([CH2:22][C:23](O)=[O:24])=[CH2:21]>>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=2)[C:5]([F:17])=[CH:4][C:3]=1[N:18]1[C:23](=[O:24])[CH2:22][CH:20]([C:19]([OH:27])=[O:26])[CH2:21]1Komponenten
3
Versuchsvorschrift
In an analogous manner to that described in Example 1a), 2,5-difluoro-4-(3-fluorobenzyloxy)-phenylamine was reacted with itaconic acid to yield (RS)-1-[2,5-difluoro-4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid (34.5% of theory) as a grey solid; MS: m/e=363 (M−H)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-1f4601ae1fa34d498ba33f08f363fd91
- Quelldatensatz
- uspto-grants-2006_10