Triphenylphosphine → HCID 69664641, Verbindung

HRID 1245333Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1245333
[OH:1][C:2]1[CH:14]=[CH:13][C:5]2[C:6]([C:9]([F:12])([F:11])[F:10])=[N:7][O:8][C:4]=2[C:3]=1[CH2:15][CH2:16][CH3:17].[Si:18]([O:25][CH2:26][CH:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH:28]1O)([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CC(OC(/N=N/C(OC(C)C)=O)=O)C>>[Si:18]([O:25][CH2:26][C@H:27]1[CH2:28][CH2:29][CH2:30][CH2:31][C@H:32]1[O:1][C:2]1[CH:14]=[CH:13][C:5]2[C:6]([C:9]([F:12])([F:11])[F:10])=[N:7][O:8][C:4]=2[C:3]=1[CH2:15][CH2:16][CH3:17])([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19]

Komponenten

5

Edukt 4

HCID 11776TriphenylphosphineHCID 5363146Diisopropyl azodicarboxylateHCID 452576462-({[tert-Butyl(dimethyl)silyl]oxy}methyl)cyclohexan-1-olHCID 1358008127-Propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-ol

Produkt 1

HCID 69664641HCID 69664641, Verbindung

Versuchsvorschrift

A mixture of 6-hydroxy-7-propyl-3-(trifluoromethyl)-1,2-benzisoxazole (730 mg, 2.98 mmol), 2-({tert-butyl(dimethyl)silyloxy}methyl)-cyclohexanol (800 mg, 3.28 mmol) from this Example step 1, and triphenylphosphine (1.02 g, 3.874 mmol) was dissolved in dry benzenes (16 mL). Diisopropylazodicarboxylate (0.78 mL, 3.874 mmol) was added dropwise. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated in vacuo and the residue purified by chromatography on silica gel using acetone and hexane (1:99) to give the title compound.

Aufarbeitung

  1. customThe solvent was evaporated in vacuo
  2. customthe residue purified by chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-1c13846d93fd460ab599c5db2db297b3
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07125865B2

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