Dimethylformamide → 3-(2-Bromophenoxy)-1-(2-methoxyethyl)pyrrolidine

3-(2-Bromophenoxy)pyrrolidine (1.23 g), 1-bromo-2-methoxyethane (0.526 ml) and potassium carbonate (842 mg) were mixed with dimethylformamide (50 ml) and stirred for two days. The mixture was added to water (100 ml). The mixture was extracted with diethyl ether (3×50 ml), washed with water (2×50 ml), brine (2×30 ml), dried (MgSO4) and concentrated in vacuo. Purification was achieved using cation exchange chromatography eluting with ammonia/methanol/dichloromethane mixtures yielding product as a clear oil (0.8 g).

1. extractionThe mixture was extracted with diethyl ether (3×50 ml)
2. washwashed with water (2×50 ml), brine (2×30 ml)
3. dry with materialdried (MgSO4)
4. concentrationconcentrated in vacuo
5. customPurification
6. washeluting with ammonia/methanol/dichloromethane mixtures

ORD-Eintrag

ord-ba1dbbf0f40b4612bb88e784533754ff

Quelldatensatz

uspto-grants-2006_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07125896B2