Triethylamine → 1-Isopropylpyrrolidin-3-yl methanesulphonate

HRID 1245864Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1245864
[CH:1]([N:4]1[CH2:8][CH2:7][CH:6]([OH:9])[CH2:5]1)([CH3:3])[CH3:2].C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1(C)C=CC=CC=1>[CH3:17][S:18]([O:9][CH:6]1[CH2:7][CH2:8][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5]1)(=[O:20])=[O:19]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 113095221-Isopropyl-3-pyrrolidinol

Produkt 1

HCID 219143101-Isopropylpyrrolidin-3-yl methanesulphonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of 1-isopropylpyrrolidin-3-ol (2.0 ml) and triethylamine (2.5 ml) in toluene (25 ml) was cooled to 0° C. and methanesulphonyl chloride (1.4 ml) was added dropwise with stirring. The mixture was allowed to warm to ambient temperature and is stirred for a further 2 h. The reaction was filtered and the filtrate evaporated to an oil which was used immediately.

Aufarbeitung

  1. stirringis stirred for a further 2 h
  2. filtrationThe reaction was filtered
  3. customthe filtrate evaporated to an oil which

Quellen und Nachweise

ORD-Eintrag
ord-ed3c7d0be0ba42f19ab36df53cbbbbe0
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07125896B2

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