Sodium Azide → 4-Azidomethyl-2-fluorobenzonitrile

HRID 1246670Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1246670
CS(O[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[C:9]([F:15])[CH:8]=1)(=O)=O.[N-:16]=[N+:17]=[N-:18].[Na+]>O>[N:16]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[C:9]([F:15])[CH:8]=1)=[N+:17]=[N-:18]

Komponenten

4

Edukt 2

HCID 33557Sodium AzideHCID 219046204-Cyano-3-fluorobenzyl methanesulfonate

Produkt 1

HCID 219046434-Azidomethyl-2-fluorobenzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To an ice cooled solution of 4-cyano-3-fluorobenzyl methanesulfonate (1.8 g, 7.9 mmol; see step (iii) above) was added sodium azide (0.80 g, 0.012 mol). The mixture was stirred overnight and then poured into 200 mL of water and extracted three times with diethyl ether. The combinied ethereal phase was washed five times with water, dried (Na2SO4) and evaporated. The crude colourless oil could be used without further purification. Yield: 1.2 g (87%).

Aufarbeitung

  1. extractionextracted three times with diethyl ether
  2. washThe combinied ethereal phase was washed five times with water
  3. dry with materialdried (Na2SO4)
  4. customevaporated
  5. customThe crude colourless oil could be used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-da32e1c4ff634be79887df2bdc4d9ffa
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07129233B2

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