Benzyl (S)-2-(7-methoxy-1H-pyrazolo[3,4-e]benzoxazol-1-yl)-1-methylethylcarbamate → (S)-2-(7-Methoxy-1H-pyrazolo[3,4-e]benzoxazol-1-yl)-1-methylethylamine

HRID 1247010Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1247010
[CH3:1][O:2][C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]3[CH:12]=[N:13][N:14]([CH2:15][C@@H:16]([NH:18]C(=O)OCC4C=CC=CC=4)[CH3:17])[C:8]=3[C:6]=2[N:7]=1>CO.[Pd]>[CH3:1][O:2][C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]3[CH:12]=[N:13][N:14]([CH2:15][C@@H:16]([NH2:18])[CH3:17])[C:8]=3[C:6]=2[N:7]=1

Komponenten

4

Edukt 1

HCID 86604076Benzyl (S)-2-(7-methoxy-1H-pyrazolo[3,4-e]benzoxazol-1-yl)-1-methylethylcarbamate

Produkt 1

HCID 11988964(S)-2-(7-Methoxy-1H-pyrazolo[3,4-e]benzoxazol-1-yl)-1-methylethylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of the product from Step E (60 mg, 0.157 mmol) in methanol (10 mL) was added 10% palladium-on-carbon (20 mg) and the mixture was stirred under an atmosphere of hydrogen at room temperature for 18 h. The reaction mixture was filtered and evaporated to a colorless oil (30 mg): LC/MS m/z 247.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customevaporated to a colorless oil (30 mg)

Quellen und Nachweise

ORD-Eintrag
ord-f32c1e8ecd9a49238595b28697e2b1d8
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07129257B1

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