Iodoethane → HCID 69290924, Verbindung

HRID 1247340Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1247340
[CH2:1]([O:3][C:4](=[O:17])[CH:5]([C:7]1[C:12]([F:13])=[CH:11][C:10]([O:14][CH3:15])=[CH:9][C:8]=1[F:16])[OH:6])[CH3:2].[CH2:18](I)[CH3:19]>C1(C)C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:17])[CH:5]([C:7]1[C:12]([F:13])=[CH:11][C:10]([O:14][CH3:15])=[CH:9][C:8]=1[F:16])[O:6][CH2:18][CH3:19])[CH3:2]

Komponenten

4

Edukt 2

HCID 6340Iodoethane2×HCID 69290984HCID 69290984, Verbindung

Produkt 1

HCID 69290924HCID 69290924, VerbindungAusbeute 100,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a suspension of (RS)-(2,6-difluoro-4-methoxy-phenyl)-hydroxy-acetic acid ethyl ester (13.06 g) and Ag2O (24.58 g) in toluene (100 ml) was added ethyl iodide (24.81 g). The mixture was heated to reflux for 2.5 h. Ethyl iodide (24.81 g) and Ag2O (12.29 g) were added and the mixture was refluxed for a further 7 h. The solid was filtered off and the filtate was concentrated to give (RS)-(2,6-difluoro-4-methoxy-phenyl)-ethoxy-acetic acid ethyl ester (14.6 g). Light yellow oil. MS 274.1 ([M]+)

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 2.5 h
  3. temperaturethe mixture was refluxed for a further 7 h
  4. filtrationThe solid was filtered off
  5. concentrationthe filtate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-62330126982a4072ab1b9d27ce5ec46d
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07129238B2

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