Water → 5-Fluoro-2-(trifluoromethyl)phenylacetonitrile

HRID 1247565Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1247565
[C-:1]#[N:2].[K+].[F:4][C:5]1[CH:6]=[CH:7][C:8]([C:13]([F:16])([F:15])[F:14])=[C:9]([CH:12]=1)[CH2:10]Br.O>C(O)C.C(OCC)(=O)C>[F:4][C:5]1[CH:6]=[CH:7][C:8]([C:13]([F:16])([F:15])[F:14])=[C:9]([CH2:10][C:1]#[N:2])[CH:12]=1

Komponenten

6

Edukt 3

HCID 962WaterHCID 9032Potassium CyanideHCID 27375785-Fluoro-2-(trifluoromethyl)benzyl bromide

Produkt 1

HCID 27376045-Fluoro-2-(trifluoromethyl)phenylacetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

1.95 g (30 mmol) of potassium cyanide is added to a solution of 5.14 g (20 mmol) of 5-fluoro-2-trifluoromethylbenzyl bromide in 45 ml of ethanol/8 ml of water, and it is stirred for 64 hours at room temperature. The reaction solution is diluted with ethyl acetate and extracted with saturated sodium bicarbonate solution. The organic phase is washed with water, dried and concentrated by evaporation. The remaining residue is purified by bulb tube distillation and recrystallized. Yield: 3.6 g (89%).

Aufarbeitung

  1. extractionextracted with saturated sodium bicarbonate solution
  2. washThe organic phase is washed with water
  3. customdried
  4. concentrationconcentrated by evaporation
  5. customThe remaining residue is purified by bulb tube
  6. distillationdistillation
  7. customrecrystallized

Quellen und Nachweise

ORD-Eintrag
ord-0ba409e413604d19aff172b009b4e436
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07129270B2

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