1-Methyl-6-phenylpyrimidine-2,4(1H,3H)-dione → 1-Methyl-6-phenyldihydropyrimidine-2,4(1H,3H)-dione

HRID 1248036Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1248036
[CH3:1][N:2]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:8][C:6](=[O:7])[NH:5][C:3]1=[O:4]>CN(C)C=N.[Pd]>[CH3:1][N:2]1[CH:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8][C:6](=[O:7])[NH:5][C:3]1=[O:4]

Komponenten

4

Edukt 1

HCID 123003501-Methyl-6-phenylpyrimidine-2,4(1H,3H)-dione

Produkt 1

HCID 130862351-Methyl-6-phenyldihydropyrimidine-2,4(1H,3H)-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 12669390N,N-DimethylmethanimidamideLösungsmittel

Versuchsvorschrift

A solution of 1-methyl-6-phenyluracil (0.65 g) in dimethylformamidine (15 ml) is treated with 10 percent palladium on carbon and reduced at 40 p.s.i. for 20 hours. The catalyst is then filtered and the filtrate evaporated to a crystalline residue. The crystallization from acetonitrile provides 5,6-dihydro-1-methyl-6-phenyl-2,4-pyrimidine-dione, m.p. 155°-6° C.

Aufarbeitung

  1. filtrationThe catalyst is then filtered
  2. customthe filtrate evaporated to a crystalline residue
  3. customThe crystallization from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-ee68f0e007e0423bb4087c1002908c19
Quelldatensatz
uspto-grants-1985_06
Patentnummer
US04521599

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