Potassium Hydroxide → HCID 20279048, Verbindung

HRID 1248193Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1248193
[CH2:1]([C:5]([CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)([C:11]([O:13]CC)=[O:12])[C:6]([O:8]CC)=[O:7])[CH2:2][CH2:3][CH3:4].[OH-].[K+]>O.CO>[CH2:1]([C:5]([CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)([C:11]([OH:13])=[O:12])[C:6]([OH:8])=[O:7])[CH2:2][CH2:3][CH3:4]

Komponenten

5

Edukt 2

HCID 14797Potassium HydroxideHCID 20279073HCID 20279073, Verbindung

Produkt 1

HCID 20279048HCID 20279048, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A mixture of diethyl 2-n-butyl-2-(cyclohexylmethyl)malonate (1.8 g) and potassium hydroxide (10 g) in water (10 ml) and methanol (10 ml) were heated under reflux for 4 hours. The methanol was evaporated under reduced pressure and the residue treated with water (50 ml), cooled to 0° C., and acidified with concentrated hydrochloric acid. The product was extracted with ethyl acetate and the extracts washed with brine, dried (MgSO4) and evaporated to give 2-n-butyl-2-(cyclohexylmethyl)malonic acid. Without further purification the acid was heated to about 160° until the evolution of carbon dioxide ceased, and cooled to give 2-(cyclohexylmethyl)hexanoic acid.

Aufarbeitung

  1. temperaturewere heated
  2. temperatureunder reflux for 4 hours
  3. customThe methanol was evaporated under reduced pressure
  4. additionthe residue treated with water (50 ml)
  5. extractionThe product was extracted with ethyl acetate
  6. washthe extracts washed with brine
  7. dry with materialdried (MgSO4)
  8. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-c6a1997e27b145ceae233f77a97c5dbc
Quelldatensatz
uspto-grants-1985_06
Patentnummer
US04522948

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