Methane → 6-Ethyl-5-propanoylpyridin-2(1H)-one

HRID 1248461Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1248461
[CH2:1]([C:3]1[NH:4][C:5](=[O:16])[C:6](=[CH:10][C:11]=1[C:12](=[O:15])[CH2:13][CH3:14])C(O)=O)[CH3:2].C>C(O)C>[CH2:1]([C:3]1[NH:4][C:5](=[O:16])[CH:6]=[CH:10][C:11]=1[C:12](=[O:15])[CH2:13][CH3:14])[CH3:2]

Komponenten

4

Edukt 2

HCID 297MethaneHCID 132365116-Ethyl-2-oxo-5-propanoyl-1,2-dihydropyridine-3-carboxylic acid

Produkt 1

HCID 132365086-Ethyl-5-propanoylpyridin-2(1H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

C-2. 6-Ethyl-5-(n-propanoyl)-2(1H)-pyridinone--A 15 g portion of 6-ethyl-1,2-dihydro-2-oxo-5-(n-propanoyl)nicotinic acid was heated in an oil bath at 235°-240° C. for 5 hours, cooled and the reaction mixture dissolved in hot ethanol, treated with decolorizing charcoal and filtered. The filtrate was evaporated in dryness and the residue recrystallized from isopropyl alcohol to yield 8.2 g of 6-ethyl-5-(n-propanoyl)-2(1H)-pyridinone, m.p. 138°-140° C.

Aufarbeitung

  1. temperaturecooled
  2. filtrationfiltered
  3. customThe filtrate was evaporated in dryness
  4. customthe residue recrystallized from isopropyl alcohol

Quellen und Nachweise

ORD-Eintrag
ord-39d6486eb20447b08dbe449b738d3e48
Quelldatensatz
uspto-grants-1985_06
Patentnummer
US04524149

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