HCID 178508524, Verbindung → HCID 178460095, Verbindung

HRID 1248515Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1248515
[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[C:5]([N+:9]([O-])=O)=[CH:4][N:3]=1>C(OC(=O)CC)(=O)CC>[NH2:9][C:5]1[C:6]([OH:8])=[N:7][C:2]([NH:1][C:6](=[O:8])[CH2:5][CH3:4])=[N:3][CH:4]=1

Komponenten

3

Edukt 1

HCID 178508524HCID 178508524, Verbindung

Produkt 1

HCID 178460095HCID 178460095, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31263Propionic anhydrideLösungsmittel

Versuchsvorschrift

7.8 gm (0.055 mol) of 2-amino-4-hydroxy-5-nitropyrimidine are heated for 4 hours to 140° C. in 50 ml of propionic acid anhydride. The mixture is cooled and the precipitated product is extracted and washed with ether. The compound is suspended in 200 ml of dimethyl formamide and hydrogenated at room temperature and normal pressure with 1 gm of Pd/C as catalyst.

Aufarbeitung

  1. temperatureThe mixture is cooled
  2. extractionthe precipitated product is extracted
  3. washwashed with ether
  4. customis suspended in 200 ml of dimethyl formamide and hydrogenated at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-4c5fdd6339f544fa9aa8925130e62c43
Quelldatensatz
uspto-grants-1985_06
Patentnummer
USRE031926

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