Hydrazine hydrate (1:1) → 3,3a,4,5,6,7-hexahydro-2H-indazole

HRID 12488

Reaktionsgleichung

Reaktionsgleichung von HRID 12488
O.[NH2:2]N.C[N:5]([CH2:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=O)C>CCCCO>[N:2]1[NH:5][CH2:7][CH:8]2[C:9]=1[CH2:10][CH2:11][CH2:12][CH2:13]2

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 858382-((Dimethylamino)methyl)cyclohexanone

Produkt 1

HCID 593393383,3a,4,5,6,7-hexahydro-2H-indazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel2×

Versuchsvorschrift

Hydrazine hydrate (28.0 mL) was dissolved in n-BuOH (200 mL) and cooled in an ice bath. A solution of 2-dimethylaminomethyl-cyclohexanone (64.0 g) in n-BuOH (50 mL) was added dropwise, the mixture was slowly warmed and refluxed for 20 hours. The solvent was evaporated under reduced pressure.

Aufarbeitung

  1. temperaturecooled in an ice bath
  2. temperaturethe mixture was slowly warmed
  3. temperaturerefluxed for 20 hours
  4. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d60c876a3fb140c791fbe1953581d169
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728018B2

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