Methanesulfonic Acid → 8-Chloro-5-nitroacridine-2,9-diol

HRID 1248831Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1248831
[Cl:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([O:17]CC4C=CC=CC=4)[CH:12]=3)[NH:7][C:6]=2[C:5]([N+:25]([O-:27])=[O:26])=[CH:4][CH:3]=1.CS(O)(=O)=O>C(O)(=O)C>[Cl:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([OH:17])[CH:12]=3)[NH:7][C:6]=2[C:5]([N+:25]([O-:27])=[O:26])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 6395Methanesulfonic AcidHCID 135883221-Chloro-4-nitro-7-(phenylmethoxy)-9(10H)-acridinone

Produkt 1

HCID 135882308-Chloro-5-nitroacridine-2,9-diol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a stirred and boiling mixture of 26.7 g of 1-chloro-4-nitro-7-(phenylmethoxy)-9(10H)-acridinone in 1.9 l of glacial acetic acid was added 13.0 ml of methanesulfonic acid. Heating and stirring were continued for seven hours and the mixture was filtered. The precipitate was suspended in 250 ml of boiling glacial acetic acid, cooled to 60°, collected, washed with water and then methanol, and dried providing the title compound, mp above 325° C.

Aufarbeitung

  1. temperatureHeating
  2. stirringstirring
  3. filtrationthe mixture was filtered
  4. temperaturecooled to 60°
  5. customcollected
  6. washwashed with water
  7. dry with materialmethanol, and dried

Quellen und Nachweise

ORD-Eintrag
ord-706d21d94aac4a13903d4d70fe288ebf
Quelldatensatz
uspto-grants-1986_12
Patentnummer
US04626540

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