Sodium Carbonate → HCID 13292184, Verbindung

HRID 1248924Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1248924
[CH3:1][CH:2]([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][CH:7]=1)[CH2:3]Cl.[CH3:13][C@H:14]1[O:19][C@@H:18]([CH3:20])[CH2:17][NH:16][CH2:15]1.C([O-])([O-])=O.[Na+].[Na+]>O>[Br:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][CH:2]([CH3:1])[CH2:3][N:16]2[CH2:15][C@H:14]([CH3:13])[O:19][C@H:18]([CH3:20])[CH2:17]2)=[CH:7][CH:8]=1

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 6415002,6-Dimethylmorpholine, cis-HCID 132921781-Bromo-4-(3-chloro-2-methylpropyl)benzene

Produkt 1

HCID 13292184HCID 13292184, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

15 parts of 2-methyl-3-(4-bromophenyl)-propyl chloride and 28 parts of cis-2,6-dimethylmorpholine were stirred at 150° C. for 8 hours. The reaction mixture was cooled, poured into 100 parts of water, brought to pH 9-10 with saturated aqueous Na2CO3 solution and extracted with methylene chloride. The organic phase was dried and concentrated and the residue was distilled to give, at a boiling point of 100°-102° C./0.01 mbar, 15.8 parts of 4-[3-(4-bromophenyl)-2-methylpropyl]-cis-2,6-dimethylmorpholine of nD22 1.5265.

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted with methylene chloride
  3. customThe organic phase was dried
  4. concentrationconcentrated
  5. distillationthe residue was distilled

Quellen und Nachweise

ORD-Eintrag
ord-7e4ca8d8015f4d1eba11f296228c7812
Quelldatensatz
uspto-grants-1986_12
Patentnummer
US04628048

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