Hydrazine hydrate (1:1) → (3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carbohydrazide

HRID 1249101Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1249101
[CH2:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH2:4][C@@H:3]([C:14]([O:16]CC)=O)[NH:2]1.O.[NH2:20][NH2:21]>CN(C)C=O>[CH2:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH2:4][C@@H:3]([C:14]([NH:20][NH2:21])=[O:16])[NH:2]1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 1079579ethyl (3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylate

Produkt 1

HCID 7109654(3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carbohydrazideAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of ethyl (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (4.9 g), hydrazine hydrate (10 ml) and dimethylformamide (50 ml) is allowed to stand at room temperature overnight. The reaction mixture is is distilled under reduced pressure to remove the solvent. The residue is treated with ethyl acetate to give the title compound (3.40 g, 74%) as powder.

Aufarbeitung

  1. distillationThe reaction mixture is is distilled under reduced pressure
  2. customto remove the solvent
  3. additionThe residue is treated with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-7bb566fabe9947ca831ad8d0c22c6d56
Quelldatensatz
uspto-grants-1986_12
Patentnummer
US04628057

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