Trimethylsilyl cyanide → 2-(3-Bromophenyl)-2-methoxyethan-1-amine
Reaktionsgleichung
CO[CH:3]([O:11][CH3:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[CH:5]=1.C[Si]([C:17]#[N:18])(C)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>[I-].[Zn+2].[I-].C(#N)C>[CH3:12][O:11][CH:3]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[CH:5]=1)[CH2:17][NH2:18]Komponenten
6
Versuchsvorschrift
1-Methoxy-1-(3-bromophenyl)acetonitrile was prepared from 3-bromobenzaldehyde dimethyl acetal and trimethylsilyl cyanide, using zinc iodide as catalyst, by an analogous procedure to that described in Example X1. Reduction of the acetonitrile with lithium aluminium hydride by an analogous procedure to that described in Example X2 gave the title compound.
Quellen und Nachweise
- ORD-Eintrag
- ord-9cc7b076408d44caa43e11ed6f07988e
- Quelldatensatz
- uspto-grants-1986_12
- Patentnummer
- US04629737
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