Methanol → HCID 18396724, Verbindung

HRID 1249658Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1249658
[CH2:1]([NH:13][C:14]([N:16]1[CH:20]=[CH:19]N=[CH:17]1)=[O:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].CNC[C@@H:24]([C@H:26]([C@@H:28]([C@@H:30](CO)[OH:31])[OH:29])[OH:27])[OH:25].C[OH:35]>>[CH2:1]([NH:13][C:14]([N:16]([CH3:17])[CH2:20][C@@H:19]([C@H:24]([C@@H:26]([C@@H:28]([CH2:30][OH:31])[OH:29])[OH:27])[OH:25])[OH:35])=[O:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 8567N-Methyl-D-glucamineHCID 18328494HCID 18328494, Verbindung

Produkt 1

HCID 18396724HCID 18396724, VerbindungAusbeute 80 %

Versuchsvorschrift

42 g of 1-N-(dodecylaminocarbonyl)imidazole and 32 g of N-methyl-D-glucamine were suspended, under an inert atmosphere, in 400 cm3 of methanol. The reaction mixture was kept stirring at reflux for 4 hours. The reaction mixture was cooled with an ice bath and the precipitate was then filtered off. It was washed with 500 cm3 of water and then dried. 49 g (80% yield) of N-dodecylaminocarbonyl-N-methyl-D-glucamine were obtained in the form of a white powder.

Aufarbeitung

  1. temperatureat reflux for 4 hours
  2. temperatureThe reaction mixture was cooled with an ice bath
  3. filtrationthe precipitate was then filtered off
  4. washIt was washed with 500 cm3 of water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-6c3d0a2f0fc447b6b9ad64db243ca2e6
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06335024B2

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