Hydrochloric Acid → HCID 68434078, Verbindung

HRID 1250366Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1250366
C(O)C.[CH:4]1([N:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:21]4[CH:22]=[C:23]5[C:27](=[CH:28][CH:29]=4)[C@@H:26]([CH3:30])[NH:25][CH2:24]5)[C:15]=3[O:17][CH:18]([F:20])[F:19])[C:10](=[O:31])[C:9]([C:32]([OH:34])=[O:33])=[CH:8]2)[CH2:6][CH2:5]1.[ClH:35]>O>[ClH:35].[CH:4]1([N:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:21]4[CH:22]=[C:23]5[C:27](=[CH:28][CH:29]=4)[C@@H:26]([CH3:30])[NH:25][CH2:24]5)[C:15]=3[O:17][CH:18]([F:20])[F:19])[C:10](=[O:31])[C:9]([C:32]([OH:34])=[O:33])=[CH:8]2)[CH2:6][CH2:5]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 124093Garenoxacin

Produkt 1

HCID 68434078HCID 68434078, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

In 20 ml of 50% water-containing ethanol is suspended 1.0 g of (R)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid and the suspension is then warmed to 50° C., after which 0.41 ml of 6 moles/liter hydrochloric acid is added thereto to form a uniform solution. Subsequently, the solution is stirred at the same temperature for 10 minutes and then filtered. The filtrate is cooled to room temperature and the crystals deposited are thereafter collected by filtration to obtain 0.56 g of (R)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride.

Aufarbeitung

  1. customto form a uniform solution
  2. filtrationfiltered
  3. temperatureThe filtrate is cooled to room temperature
  4. filtrationthe crystals deposited are thereafter collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-ae5e628114f84ebbaae94d97582d56e0
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06337399B1

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