Allylamine → 2-Allylamino-4-isopropylamino-6-nitroquinazoline hydrochloride

HRID 1250583

Reaktionsgleichung

Reaktionsgleichung von HRID 1250583
[Cl:1][C:2]1[N:11]=[C:10]([NH:12][CH:13]([CH3:15])[CH3:14])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:16]([O-:18])=[O:17])[CH:8]=2)[N:3]=1.[CH2:19]([NH2:22])[CH:20]=[CH2:21]>O>[ClH:1].[CH2:19]([NH:22][C:2]1[N:11]=[C:10]([NH:12][CH:13]([CH3:15])[CH3:14])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:16]([O-:18])=[O:17])[CH:8]=2)[N:3]=1)[CH:20]=[CH2:21]

Komponenten

4

Edukt 2

HCID 7853AllylamineHCID 183264282-Chloro-4-isopropylamino-6-nitroquinazoline

Produkt 1

HCID 183265012-Allylamino-4-isopropylamino-6-nitroquinazoline hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To 870 mg (3.26 mmol) of 2-chloro-4-isopropylamino-6-nitroquinazoline was added 3.81 g (66.64 mmol) of allylamine, followed by stirring at room temperature for 4 hours. To the reaction solution was added water, followed by extraction with ethyl acetate, washing with brine and drying over anhydrous sodium sulfate. After the solvent was distilled off, the residue was purified by a silica gel column to give 895 mg (yield: 95.7%) of a free base compound of the title compound.

Aufarbeitung

  1. extractionfollowed by extraction with ethyl acetate
  2. washwashing with brine
  3. dry with materialdrying over anhydrous sodium sulfate
  4. distillationAfter the solvent was distilled off
  5. customthe residue was purified by a silica gel column

Quellen und Nachweise

ORD-Eintrag
ord-3452785b83ad483896bc3e4eef052c71
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06339089B2

Verknüpfte Notizen

Wird geladen…