Malononitrile → Dihydro-2H-pyran-4,4(3H)-dicarbonitrile

HRID 12506

Reaktionsgleichung

Reaktionsgleichung von HRID 12506
[C:1](#[N:5])[CH2:2][C:3]#[N:4].Br[CH2:7][CH2:8][O:9][CH2:10][CH2:11]Br.CC([O-])(C)C.[K+]>CS(C)=O.CCCC[N+](CCCC)(CCCC)CCCC.[Br-].C(Cl)Cl>[O:9]1[CH2:10][CH2:11][C:2]([C:1]#[N:5])([C:3]#[N:4])[CH2:7][CH2:8]1

Komponenten

7

Edukt 3

HCID 8010MalononitrileHCID 21521Bis(2-bromoethyl) etherHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 14537194Dihydro-2H-pyran-4,4(3H)-dicarbonitrileAusbeute 24 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 74236Tetrabutylammonium BromideKatalysatorHCID 679Dimethyl SulfoxideLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Malononitrile (5.0 g) was dissolved in DMSO (5 mL). Subsequently, bis(2-bromoethyl)ether (9.49 mL) and TBAB (1.22 g) were added, followed by portionwise addition of KOtBu (8.49 g). The mixture was stirred for 4 h. at room temperature, taken up in DCM and extracted 3 times with 5% aqueous NaHCO3. The organic phase was dried over Na2SO4 and evaporated under reduced pressure. The crude material was purified by flash chromatography eluting with PA:Et2O 65:35 (Rf=0.24, visualized with KMnO4) to give 2.49 g (24%) of a solid. 1H NMR (400 MHz, CDCl3) δ 2.24 (t, 4H), 3.87 (t, 4H).

Aufarbeitung

  1. extractionextracted 3 times with 5% aqueous NaHCO3
  2. dry with materialThe organic phase was dried over Na2SO4
  3. customevaporated under reduced pressure
  4. customThe crude material was purified by flash chromatography
  5. washeluting with PA

Quellen und Nachweise

ORD-Eintrag
ord-4052a6dbde5847328dbec77949a0b930
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728018B2

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