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Diisopropylethylamine → HCID 57276081, Verbindung

HRID 1250865
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1250865
[C:1]1([S:7]([NH:10][C@H:11]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:12][C:13]2[CH:25]=[CH:24][C:16]([O:17][CH2:18][CH2:19][CH2:20][C:21](O)=[O:22])=[CH:15][CH:14]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([N:36](C(C)C)CC)(C)C.CN(C(O[N:50]1N=NC2[CH:53]=[CH:54][CH:55]=[N:56][C:51]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>O1CCCC1.N1CCCN=C1N>[C:29]([O:28][C:26](=[O:27])[C@@H:11]([NH:10][S:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)(=[O:9])=[O:8])[CH2:12][C:13]1[CH:25]=[CH:24][C:16]([O:17][CH2:18][CH2:19][CH2:20][C:21](=[O:22])[NH:36][C:51]2[NH:50][CH2:53][CH2:54][CH2:55][N:56]=2)=[CH:15][CH:14]=1)([CH3:31])([CH3:30])[CH3:32]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 3

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 57041896HCID 57041896, Verbindung

Produkt 1

HCID 57276081HCID 57276081, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028
Tetrahydrofuran
Lösungsmittel
HCID 32874121,4,5,6-Tetrahydropyrimidin-2-amineLösungsmittel

Versuchsvorschrift

88 mg of 4-[4-((2S)-2-benzenesulfonylamino-2-tert-butoxycarbonyl-ethyl)-phenoxy]-butyric acid were dissolved in tetrahydrofuran and 22.6 mg of 1,4,5,6-tetrahydropyrimidin-2-ylamine, 123 mg of diisopropylethylamine and 79.4 mg of HATU were added. The reaction mixture was stirred overnight, and the solvent was removed in vacuo. The residue was dissolved in dichloromethane and washed with saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution. The organic phase was dried with sodium sulfate, filtered and the solvent was removed in vacuo. The residue was chromatographed on reversed-phase (C-1 8) silica gel eluting with a gradient of 10-90% acetonitrile in water. Yield 40.1 mg. MS (FAB+): m/e=545.3 (M+H)+.

Aufarbeitung

  1. customthe solvent was removed in vacuo
  2. dissolutionThe residue was dissolved in dichloromethane
  3. washwashed with saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution
  4. dry with materialThe organic phase was dried with sodium sulfate
  5. filtrationfiltered
  6. customthe solvent was removed in vacuo
  7. customThe residue was chromatographed on reversed-phase (C-1 8) silica gel eluting with a gradient of 10-90% acetonitrile in water

Quellen und Nachweise

ORD-Eintrag
ord-90f4e60d88af4e47851ef3ccb2fb27f0
Quelldatensatz
uspto-grants-2002_01
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US06340679B1

Notizen zur Reaktion

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