Methyl iodide → 4-(4-Hydroxyphenyl)butanoic acid methyl ester

HRID 1250924

Reaktionsgleichung

Reaktionsgleichung von HRID 1250924
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:4][CH:3]=1.[C:14](=O)(O)[O-].[Na+].IC>CN(C=O)C.O>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[CH:6][CH:7]=1

Komponenten

6

Edukt 3

HCID 6328Methyl iodideHCID 2799834-(4-Hydroxyphenyl)butanoic acidHCID 516892Sodium Bicarbonate

Produkt 1

HCID 1409044-(4-Hydroxyphenyl)butanoic acid methyl esterAusbeute 74,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 0.69 g of 4-(4-hydroxyphenyl)butyric acid in 10 mL of DMF was added 0.956 g of sodium bicarbonate followed by 0.36 mL of iodomethane and the resulting mixture was stirred at room temperature for 5 h. The reaction was then diluted with water, extracted with ether, dried over MgSO4, filtered and concentrated in vacuo to provide 0.553 g of methyl 4(4-hydroxyphenyl)butyrate.

Aufarbeitung

  1. extractionextracted with ether
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1acd6fb8e75e4f6cb52752d279aee71c
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06340691B1

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