Hydrochloric Acid → 9-(1,3-Benzodioxol-5-yl)-8-methyl-benzo[g][1,3]benzodioxole-7-carboxylic acid

HRID 1250941Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1250941
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:11]([CH3:27])=[C:12]([C:23]([O:25]C)=[O:24])[CH:13]=[C:14]4[C:22]=3[C:18]3[O:19][CH2:20][O:21][C:17]=3[CH:16]=[CH:15]4)=[CH:9][C:4]=2[O:3][CH2:2]1.[OH-].[Na+].Cl.O>C1COCC1.CO>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:11]([CH3:27])=[C:12]([C:23]([OH:25])=[O:24])[CH:13]=[C:14]4[C:22]=3[C:18]3[O:19][CH2:20][O:21][C:17]=3[CH:16]=[CH:15]4)=[CH:9][C:4]=2[O:3][CH2:2]1

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 18325127HCID 18325127, Verbindung

Produkt 1

HCID 4931639-(1,3-Benzodioxol-5-yl)-8-methyl-benzo[g][1,3]benzodioxole-7-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Methyl 9-(1,3-benzodioxole-5-yl)-8-methyl-naphtho[1,2-d]-1,3-dioxole-7-carboxylate was dissolved in a mixture of THF (6 ml) and methanol (3 ml). After addition of 1N NaOH (3 ml), the mixture was stirred for 4 days. 1N HCl was added to the reaction mixture, followed by addition of water. The resulting precipitate was collected by filtration to yield the title compound (264 mg). Some portions of the compound was recrystalized from methanol-chloroform to be used for elemental and instrumental analysis.

Aufarbeitung

  1. filtrationThe resulting precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-acb9eb33aa014aba95c716d86a5097d3
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06340704B1

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