Tetrahydrofuran → HCID 10976559, Verbindung

HRID 1251960Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1251960
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[C:6](=[O:14])[CH2:7][C:8]2=[O:13])([O-])=O.[H][H].[O:17]1CC[CH2:19][CH2:18]1>C(O)C.[Pd]>[C:18]([CH:7]1[C:6](=[O:14])[C:5]2[C:9](=[CH:10][CH:11]=[CH:12][C:4]=2[NH2:1])[C:8]1=[O:13])(=[O:17])[CH3:19]

Komponenten

6

Edukt 3

HCID 8028TetrahydrofuranHCID 27370564-Nitro-1H-indene-1,3(2H)-dioneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 10976559HCID 10976559, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a suspension of 20.0 g of 4-nitro-1,3-indanedione in 100 mL tetrahydrofuran and 20 mL of ethanol, 1.0 g of 10% Pd/C catalyst was added and the mixture hydrogenated at 50 psi until three molar equivalents of hydrogen were taken up. The catalyst was filtered off and solvent was removed from the filtrate under reduced pressure. Recrystallization from ethanol afforded 14.8 g of the title compound, m.p. 126°-128°.

Aufarbeitung

  1. additionwas added
  2. filtrationThe catalyst was filtered off
  3. customsolvent was removed from the filtrate under reduced pressure
  4. customRecrystallization from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-730cc5b51ac84efabced969db7e8e437
Quelldatensatz
uspto-grants-1988_05
Patentnummer
US04741765

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