2-(4-Benzylpiperazino)-6-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine → 6-Ethyl-5-oxo-2-piperazino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

HRID 1252283Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1252283
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]=[CH:16][C:17]3[C:23](=[O:24])[N:22]([CH2:25][CH3:26])[CH2:21][CH2:20][C:18]=3[N:19]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH2:25]([N:22]1[CH2:21][CH2:20][C:18]2[N:19]=[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[N:15]=[CH:16][C:17]=2[C:23]1=[O:24])[CH3:26]

Komponenten

5

Edukt 2

HCID 137841212-(4-Benzylpiperazino)-6-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 137841226-Ethyl-5-oxo-2-piperazino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidineAusbeute 96,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

In 20 ml of ethanol was dissolved 0.70 g of 2-(4-benzylpiperazino)-6-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine. Thereto was added 10% Pd-C, and the resulting mixture was stirred at 60° C. for 4 hours in a hydrogen atmosphere. After having been allowed to cool, the mixture was filtered to remove the catalyst and the filtrate was concentrated to obtain 0.50 g of 6-ethyl-5-oxo-2-piperazino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine as a crystal with an yield of 96%. The crystal was purified by immersion using ethyl acetate.

Aufarbeitung

  1. temperatureto cool
  2. filtrationthe mixture was filtered
  3. customto remove the catalyst
  4. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-80d50aaf71c8454aa406bba0069876ea
Quelldatensatz
uspto-grants-1988_05
Patentnummer
US04742165

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